Early biomarker of insulin resistance and glucose intolerance identified in a nondiabetic population

Early biomarker of insulin resistance and glucose intolerance identified in a nondiabetic population

Metabolon, Inc., the leader in metabolomics-based biomarker discovery and analysis, announced the publication of research that identified a novel, early biomarker for insulin resistance and glucose intolerance in a nondiabetic population. Co-authored by physicians and scientists from EGIR (European Group for the Study of Insulin Resistance) and Metabolon, the paper, "alpha-hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population", appears on the PLoS One website. (doi:10.1371/journal.pone.0010883 (May 28th 2010)). Please click here for the article.

Metabolon's biochemical profiling technology was deployed on plasma samples from 399 nondiabetic subjects from EGIR's large prospective RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) cohort, representing a broad spectrum of insulin sensitivity and glucose tolerance. Alpha-hydroxybutyrate was the statistically top-ranked biochemical for classifying subjects as insulin resistant or insulin sensitive. Commenting on the study results, senior RISC author Ele Ferrannini, M.D. summarized, "From this unbiased, biochemical screen, alpha-hydroxybutyrate, an intermediate metabolite of amino acid metabolism, was the strongest biochemical that marks as a single metabolic fingerprint of in vivo human insulin resistance."

Insulin resistance is an abnormal metabolic condition and a recognized clinical predictor of type 2 diabetes and cardiovascular disease, with association with obesity, certain cancers, and other metabolic diseases. Metabolon is currently developing a fasted plasma diagnostic test for insulin resistance to allow physicians to more accurately assess their at-risk patient population. As described in the article, alpha-hydroxybutyrate and other metabolites have been identified as a metabolic signature of insulin resistance.

Source: Metabolon, Inc.

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